Key result
Automated RV Mod-MPI is elevated in late-onset FGR and links to lower birth weight and Apgar scores.
Why the study?
To evaluate automated right- and left-ventricular myocardial performance index using the Samsung Hera W10 (MPI+™) system in fetuses with late-onset fetal growth restriction and explore its association with Doppler parameters and perinatal outcomes.
Does automated right- and left-ventricular Mod-MPI detect early cardiac dysfunction in fetuses with late-onset fetal growth restriction compared to healthy controls?
Observational (n=177)
Does automated right- and left-ventricular Mod-MPI detect early cardiac dysfunction in fetuses with late-onset fetal growth restriction compared to healthy controls?
p-value: p=.001
Automated right-ventricular Mod-MPI provides an objective indicator of early right-sided cardiac dysfunction and myocardial adaptation in fetuses with late-onset fetal growth restriction, preceding classical Doppler deterioration.
May warrant automated RV Mod-MPI in late-onset FGR surveillance; hypothesis-generating for validation before routine adoption ahead of Doppler changes.
Objectives To evaluate automated right‐ and left‐ventricular myocardial performance index (Mod‐MPI) using the Samsung Hera W10 (MPI+™) system in fetuses with late‐onset fetal growth restriction (FGR) and to explore its association with Doppler parameters and perinatal outcomes. Methods This prospective study included 177 singleton pregnancies between 32 and 39 weeks of gestation—87 with late‐onset FGR and 90 gestational‐age‐matched controls. Fetal echocardiography and Doppler examinations were performed using the Samsung Hera W10 system with integrated MPI+™ software. Automated right and left Mod‐MPI, atrioventricular valve E/A ratios, and Doppler indices were recorded. Neonatal outcomes were analyzed in relation to MPI measurements. Results Right‐ventricular MPI and isovolumic contraction time (ICT) were significantly increased in FGR fetuses compared with controls ( p = .001), whereas left‐ventricular MPI showed no significant difference. Umbilical artery PI and RI were higher, and CPR and umbilical peak systolic velocity were lower in FGR. Right‐sided MPI correlated negatively with gestational age, birth weight, and Apgar scores. Conclusion Automated right‐ventricular Mod‐MPI provides a reproducible, objective indicator of early cardiac dysfunction in late‐onset FGR. Elevation of right‐sided MPI and prolongation of contraction time may reflect early myocardial adaptation preceding classical Doppler deterioration.
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Toptaş et al. (2026) conducted an observational in Late-onset fetal growth restriction (n=177). Late-onset fetal growth restriction vs. Gestational-age-matched controls was evaluated on Right-ventricular MPI and isovolumic contraction time (ICT) (p=.001). Late-onset fetal growth restriction was associated with significantly increased right-ventricular myocardial performance index and isovolumic contraction time compared with controls (p = .001).
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