Key result
Multimodal imaging and histopathology successfully diagnose primary breast angiosarcoma presenting as a rapidly enlarging mass.
Why the study?
Primary breast angiosarcoma is an exceptionally rare, aggressive vascular malignancy with rapid growth and poor prognosis, often causing diagnostic and therapeutic challenges.
Case Report (n=1)
Advanced multimodal imaging and histopathological evaluation are crucial for the early recognition and diagnosis of rare primary breast angiosarcoma.
Supports multimodal imaging and histopathology for rare breast angiosarcoma diagnosis; extends evidence guiding surgical therapy.
Primary breast angiosarcoma (PBA) is an exceptionally rare and aggressive vascular malignancy, accounting for less than 0.04% of all breast cancers. It is characterized by rapid growth, high recurrence rates, and poor prognosis, often leading to diagnostic and therapeutic challenges. We report the case of a 41-year-old woman presenting with a rapidly enlarging left breast mass following trauma, initially misdiagnosed as granulomatous mastitis. Multimodal imaging, including ultrasound, contrast-enhanced ultrasound (CEUS), and magnetic resonance imaging (MRI), revealed features consistent with a vascular tumor, which was confirmed as PBA through histopathological and immunohistochemical analysis. The patient underwent a core needle biopsy followed by mastectomy. This case highlights the importance of advanced imaging techniques and histopathological evaluation in diagnosing PBA, as well as the need for early recognition and surgical intervention to improve outcomes. Further studies are required to establish standardized diagnostic and treatment protocols for this rare malignancy.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2026) conducted a case report in Primary breast angiosarcoma (n=1). Multimodal imaging and mastectomy was evaluated. Multimodal imaging and histopathological evaluation successfully diagnosed primary breast angiosarcoma in a 41-year-old woman presenting with a rapidly enlarging breast mass.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: