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March 10, 2026Cancer0 citations

Two new options for NPM1 ‐mutated relapsed, refractory acute myeloid leukemia

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LLLeah Lawrence

Key Points

  • The aim is to inform about new FDA approvals for treating specific leukemia mutations.
  • Reviewed FDA announcements regarding new treatments
  • Highlighted specific approvals for relapsed or refractory acute myeloid leukemia
  • Mentioned treatments for other related conditions
  • Revumenib and ziftomenib approved for NPM1-mutated acute myeloid leukemia
  • Daratumumab with hyaluronidase-fihj approved for high-risk smoldering multiple myeloma
  • Oral TKI sevabertinib approved for advanced HER2-mutant NSCLC

Abstract

This news section offers Cancer readers timely information on events, public policy analysis, and topical issues. In this issue, the FDA recently approved two menin inhibitors for the treatment of relapsed or refractory acute myeloid leukemia with NPM1 mutations: revumenib and ziftomenib. In addition, the FDA also approved the subcutaneous injection of anti‐CD38 monoclonal antibody daratumumab and hyaluronidase‐fihj for patients with high‐risk smoldering multiple myeloma, and oral TKI sevabertinib is approved for advanced HER2 ‐mutant NSCLC.

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Cite This Study

Leah Lawrence (2026) studied this question.

synapsesocial.com/papers/69af944f70916d39fea4b537https://doi.org/10.1002/cncr.70275
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Emerging drug profile: menin inhibitors in NPM1-mutated and KM2A-rearranged acute myeloid leukemia2026
  2. 2Therapeutic Implications of Menin Inhibitors in the Treatment of Acute Leukemia: A Critical Review2025 · 6 citations
  3. 3The promise of menin inhibitors: from approval to triplet regimens2025 · 8 citations
  4. 4A 2024 Update on Menin Inhibitors. A New Class of Target Agents against KMT2A-Rearranged and NPM1-Mutated Acute Myeloid Leukemia2024 · 72 citations
  5. 5Menin Inhibition in Acute Myeloid MLL Rearranged Leukemias: A New Target for Precision Care2026 · 1 citations