What question did this study set out to answer?

This study aims to evaluate the phytochemical profile of Moringa oleifera and its protective effects against acetaminophen-induced liver damage in mice.

March 10, 2026Journal of Functional FoodsOpen Access

Phytochemical profile and hepatoprotective activity of Moringa oleifera Lam leaf extract in acetaminophen-challenged mice

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Authors

YYYoong Soon Yong MSMichelle C. SiaoSubang Jaya Medical Centre KNKam Heng NgSubang Jaya Medical Centre

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Implication

Evaluates the hepatoprotective efficacy of Moringa oleifera extract in acetaminophen-challenged mice, suggesting its potential in health applications.

Key Points

This study aims to evaluate the phytochemical profile of Moringa oleifera and its protective effects against acetaminophen-induced liver damage in mice.
Analyzed aqueous-ethanolic extract using LC-MS/MS to identify metabolites
Conducted in vivo experiments on acetaminophen-challenged mice receiving the extract at 50 or 200 mg/kg
Assessed liver histology, serum ALT and AST levels, CYP2E1 activity, and glutathione levels
Extract improved liver histology and reduced serum ALT and AST levels in treated mice
Demonstrated moderate antioxidant activity in DPPH and FRAP assays
Downregulated proinflammatory cytokines and expression of hepatic iNOS and NF-κB
Restored glutathione levels and normalized lipid metabolism and prostaglandin profiles

Cite This Study

Yong et al. (2026) studied this question.

synapsesocial.com/papers/69af94c970916d39fea4baf0 https://doi.org/10.1016/j.jff.2026.107232

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Implication

Evaluates the hepatoprotective efficacy of Moringa oleifera extract in acetaminophen-challenged mice, suggesting its potential in health applications.

Phytochemical profile and hepatoprotective activity of Moringa oleifera Lam leaf extract in acetaminophen-challenged mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Phytochemical profile and hepatoprotective activity of Moringa oleifera Lam leaf extract in acetaminophen-challenged mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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