The OX40 / OX40L Axis Promotes Th2 Activity and Impairs Regulatory T Cell Function in Atopic Dermatitis

Key Points

• This research aims to understand how the OX40/OX40L interaction impacts T cell function in atopic dermatitis.
• Examined OX40 expression in CD4+ T cells from atopic dermatitis patients
• Analyzed interaction between T cells and OX40L-expressing cells in skin
• Evaluated effects on regulatory T cell (Treg) function and skin inflammation
• Significant increase in OX40 expression in effector and regulatory CD4+ T cells observed
• Interaction between OX40 and OX40L promotes Th2 activity
• Regulatory T cell function and anti-inflammatory capacity are downregulated.