Cycloaddition reactions produce complex skeletons using ene-allenes and different components, indicating novel synthesis opportunities.
In this study, the reaction scopes of [4+2+1] cycloaddition between ene‐allenes (from acyloxy‐enynes) with alkynes/allenes/alkenes and CO have been studied, revealing that reaching 5/7 skeletons by these reactions can be realized with high confidence. To reach 6/7 skeletons, the C 2 components can only be alkynes and allenes. High diastereo‐selectivities can be achieved for the [4+2+1] reactions for substrates with a substituent in their tethers. Ene‐allenes can also be used directly as the C 4 synthons in the [4+2+1] reactions.
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Dang et al. (2026) studied this question.
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