Cascade Construction of Diverse Thiazoloindoles via the Generation of New Indole Skeletons Under Microwave Irradiation

A highly efficient method has been developed for synthesizing various substituted 2‐methyl‐7‐aryl‐6 H ‐thiazoloindole derivatives through a microwave‐assisted cascade process involving 2‐methylbenzo[ d ]thiazol‐5‐amine or 2‐methylbenzo[ d ]thiazol‐6‐amine, 2,2‐dihydroxy‐1‐arylethan‐1‐one, and 1,3‐dicarbonyl compounds or their analogs. Notably, this three‐component transformation offers several advantages, including short reaction times, wide substrate tolerance, and the absence of harmful byproducts, delivering the target compounds in moderate to good yields.