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The aim is to develop a simple and efficient method for synthesizing Grubbs-type catalysts for olefin metathesis.

March 10, 2026Angewandte ChemieOpen Access

A Convenient, Safe, and Atom‐Economical Route to a Large Portfolio of Grubbs‐Type Catalysts for Olefin Metathesis via Four‐Coordinate Ruthenium Alkylidynes

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The aim is to develop a simple and efficient method for synthesizing Grubbs-type catalysts for olefin metathesis.
Utilized p-tolyl(trimethylsilyl)diazomethane as a carbyne donor reagent.
Reacted with [(p-cymene)RuCl2]2 in MeCN to create a chloride-bridged dinuclear complex.
Treated the complex with PCy3 or N-heterocyclic carbene to form four-coordinate ruthenium alkylidynes.
Investigated the protonation of the alkylidyne unit to generate carbene ligands.
Achieved the synthesis of a variety of Grubbs-type catalysts with high yields.
Demonstrated better ligand and atom economy compared to previous methods.
Reactions occurred under mild conditions, enhancing safety and flexibility.

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Convenient method develops a range of Grubbs-type catalysts, suggesting improved efficiency in olefin metathesis reactions.

Cui et al. (2026) studied this question.

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