What question did this study set out to answer?

To systematically develop and optimize a protocol for generating active ruthenium-based olefin metathesis catalysts in situ from commercially available, low-cost reagents.

March 8, 2019ACS CatalysisOpen Access

In Situ Generation of Ru-Based Metathesis Catalyst. A Systematic Study

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To systematically develop and optimize a protocol for generating active ruthenium-based olefin metathesis catalysts in situ from commercially available, low-cost reagents.
Assembled 18-electron arene-ruthenium complexes by combining [Ru(p-cymene)Cl2]2, SIPr·HCl, and n-BuLi.
Activated the catalytic intermediate using additives such as alkynes, cyclopropenes, and diazoesters across diverse olefin metathesis transformations, including a 2 kg scale reaction.
Generated selective and efficient catalytic systems directly in reaction mixtures without pre-isolating sensitive ruthenium complexes.
Achieved a productive turnover number (TON) of 4500 for the self-metathesis of methyl oleate on a 2 kg preparative scale.

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Implication

Systematic study demonstrates efficient in situ generation of ruthenium metathesis catalysts from inexpensive precursors, suggesting a scalable pathway for industrial chemical synthesis.

Cite This Study

Müller et al. (2019) studied this question.

synapsesocial.com/papers/6a858752f03ba6f1e32021f2 https://doi.org/10.1021/acscatal.9b00244

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Implication

Systematic study demonstrates efficient in situ generation of ruthenium metathesis catalysts from inexpensive precursors, suggesting a scalable pathway for industrial chemical synthesis.

In Situ Generation of Ru-Based Metathesis Catalyst. A Systematic Study

Key Points

Discussion

Implication

Cite This Study

In Situ Generation of Ru-Based Metathesis Catalyst. A Systematic Study

Key Points

Discussion

Implication

Cite This Study

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