What does this research mean for the field?

The novel 4-phenoxy- and 4-cyano-substituted Ph-1,2,3-triazole derivatives exhibit excellent anti-inflammatory activity with IC50 values of approximately 14 μM, selectively inhibiting COX-2. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim was to synthesize novel 1,2,3-triazole derivatives and evaluate their anti-inflammatory effects.

March 10, 2026Journal of ChemistryOpen Access

Synthesis and Evaluation of Molecular Docking and Anti‐Inflammatory Activity of New 1,2,3‐Triazole Derivatives

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The aim was to synthesize novel 1,2,3-triazole derivatives and evaluate their anti-inflammatory effects.
Synthesis of new substituted Ph-1,2,3-triazole derivatives using cycloaddition and Click chemistry.
Assessment of in vitro anti-inflammatory activity using Celecoxib as a reference drug.
Molecular docking studies to analyze COX-2 inhibitory activity and binding interactions.
4-phenoxy- and 4-cyano-substituted triazoles showed excellent anti-inflammatory activity with low IC50 values.
Molecular docking results indicated strong binding affinities between -8.3 and -9.1 kcal/mol for the derivatives.
Both phenoxy and cyano groups contributed to enhanced COX-2 inhibition.

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Implication

Demonstrates the anti-inflammatory activity of novel 1,2,3-triazole derivatives, suggesting potential therapeutic applications.

Cite This Study

Aitha et al. (2026) studied this question.

synapsesocial.com/papers/69af95b470916d39fea4d7fb https://doi.org/10.1155/joch/9411347

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Synthesis and Evaluation of Molecular Docking and Anti‐Inflammatory Activity of New 1,2,3‐Triazole Derivatives

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Implication

Cite This Study

Synthesis and Evaluation of Molecular Docking and Anti‐Inflammatory Activity of New 1,2,3‐Triazole Derivatives

Key Points

Discussion

Implication

Cite This Study