What question did this study set out to answer?

To provide an overview of AestheFill® composition, mechanisms, efficacy, safety, and related clinical practices.

AestheFill® in Aesthetic Medicine: From Materials Science to Clinical Practice

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Narrative review summarizes clinical efficacy and safety of AestheFill® in aesthetic medicine, suggesting improved techniques and outcomes.

To provide an overview of AestheFill® composition, mechanisms, efficacy, safety, and related clinical practices.
Conducted a narrative review of various studies, including preclinical and clinical trials.
Analyzed consensus and guideline publications on AestheFill® properties and clinical outcomes.
Emphasized preparation and injection techniques through structured searches of databases and reference lists.
Preclinical studies show PDLLA microspheres support collagen deposition and tissue integration.
Clinical trials demonstrate comparable efficacy to hyaluronic acid while maintaining safety.
Optimized reconstitution and injection techniques reduce complications like nodules.

Lin et al. (2026) studied this question.

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Narrative review summarizes clinical efficacy and safety of AestheFill® in aesthetic medicine, suggesting improved techniques and outcomes.