The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy for Mismatch Repair Proficient ( pMMR )/Microsatellite Stable ( MSS ) Colorectal Cancer Liver Metastases ( CRLM )

Q: What does this research mean for the field?

Hepatic arterial infusion chemotherapy (HAIC) is effective and well-tolerated in patients with mismatch repair proficient/microsatellite stable colorectal cancer liver metastases who are refractory to systemic therapy. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yawei Li; Junqing Xi; Xiaoyu Huang; Yingen Luo; Xiaowu Zhang; Xiao Li

doi:10.1002/cam4.71663

March 1, 2026Cancer MedicineOpen Access

The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy for Mismatch Repair Proficient ( pMMR )/Microsatellite Stable ( MSS ) Colorectal Cancer Liver Metastases ( CRLM )

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Key Points

To evaluate the efficacy and safety of hepatic arterial infusion chemotherapy in pMMR/MSS colorectal cancer liver metastases.
Conducted analysis on patients undergoing HAIC for colorectal cancer liver metastases
Evaluated effectiveness and tolerance of HAIC in patients refractory to systemic therapy
Investigated the potential additive value of targeted therapy alongside HAIC
HAIC shown to be effective and well-tolerated in treated patients
Patients demonstrated a response despite previous systemic therapy failures
Further research needed to assess synergy with targeted therapy

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Implication

HAIC demonstrates effectiveness and safety in pMMR/MSS colorectal cancer liver metastases, suggesting a need for further investigation of targeted therapy.

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Li et al. (2026) studied this question.

synapsesocial.com/papers/69b257a296eeacc4fcec65c6 https://doi.org/10.1002/cam4.71663

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The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy for Mismatch Repair Proficient ( pMMR )/Microsatellite Stable ( MSS ) Colorectal Cancer Liver Metastases ( CRLM )

Key Points

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Abstract

Discussion

Cite This Study

The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy for Mismatch Repair Proficient ( pMMR )/Microsatellite Stable ( MSS ) Colorectal Cancer Liver Metastases ( CRLM )

Key Points

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Implication

Abstract

Discussion

Cite This Study

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