Key result
Female sex is linked to ~15% higher 5-year overall survival in Ewing sarcoma versus males.
In elderly patients over 65 with Ewing sarcoma, initial stage and surgical treatment are the most significant independent predictors of cancer-specific survival.
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Sex should inform prognostic counseling in Ewing sarcoma; hypothesis-generating for biological differences and requires prospective validation.
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Doğan et al. (2026) studied this question. Female patients with Ewing sarcoma had a 15% higher overall survival rate at 5 years (81%) compared to male patients (66%), p<0.001.
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