141P Inflammatory prognostic factors and long-term outcomes of chondrosarcoma patients treated with palliative chemotherapy

March 1, 2026ESMO rare cancers.Open Access

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Key Points

To investigate the impact of inflammatory prognostic factors on the long-term outcomes of chondrosarcoma patients undergoing palliative chemotherapy, with a focus on sex differences.
Analyzed data from 402 chondrosarcoma patients treated with palliative chemotherapy.
Compared baseline characteristics, histologic subtypes, and treatment outcomes between male and female patients.
Evaluated overall survival (OS) and disease-free survival (DFS) rates.
Female patients showed a significant advantage in overall survival (81% vs. 66% at 5 years, p<0.001).
Disease-free survival was also higher in females (72% vs. 59%, p=0.0004).
Differences in tumor subtypes and locations were noted but did not explain survival advantages.

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Analyzing inflammatory factors affecting long-term outcomes in chondrosarcoma patients suggests significant sex differences.

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Czarnecka et al. (2026) studied this question.

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