Five things to know about ... D-dimer testing in clinical practice

Q: What does this research mean for the field?

D-dimer testing is effective for excluding venous thromboembolism (VTE), particularly in ruling out deep vein thrombosis (DVT) and pulmonary embolism (PE). Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Maya Stein; Eric Kaplovitch; Seema Marwaha

doi:10.1503/cmaj.251356

March 8, 2026Canadian Medical Association JournalOpen Access

Five things to know about ... D-dimer testing in clinical practice

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Key Points

Examine the role of D-dimer testing in effectively excluding venous thromboembolism (VTE).
Review clinical applications of D-dimer testing
Analyze sensitivity and specificity for diagnosing VTE
Discuss implications of elevated D-dimer levels in various conditions
Low D-dimer levels reliably exclude DVT and PE
Elevated D-dimer levels are nonspecific and may indicate other conditions
Testing may be influenced by age, infection, and cancer status

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Implication

Observational reviews identify the utility of D-dimer testing for VTE exclusion, suggesting its practical relevance in diagnosis.

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Cite This Study

Stein et al. (2026) studied this question.

synapsesocial.com/papers/69b257cd96eeacc4fcec6d62 https://doi.org/10.1503/cmaj.251356

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Five things to know about ... D-dimer testing in clinical practice

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Five things to know about ... D-dimer testing in clinical practice

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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