Key result
D-dimer testing, when measured by a sensitive assay and combined with pretest clinical probability, can safely exclude venous thromboembolism in symptomatic outpatients.
Why the study?
What are the clinical applications, merits, and pitfalls of D-dimer testing in laboratory practice for thrombosis-related conditions?
Population
Patients evaluated for thrombosis-related clinical conditions, including suspected venous thromboembolism…
Design
Review
Authors
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Supports D-dimer use for outpatient VTE exclusion in low-probability cases; leaves open assay standardization and broader validation.
What are the clinical applications, merits, and pitfalls of D-dimer testing in laboratory practice for thrombosis-related conditions?
D-dimer is a valuable laboratory tool for excluding VTE in low-probability patients, assessing recurrence risk, and managing DIC, despite its poor positive predictive value.
Armando Tripodi (2012) conducted a review in Venous thromboembolism (VTE) and Disseminated intravascular coagulation (DIC). D-dimer testing was evaluated. D-dimer testing, when measured by a sensitive assay and combined with pretest clinical probability, can safely exclude venous thromboembolism in symptomatic outpatients.
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