What question did this study set out to answer?

To summarize the challenges and clinical significance of D-dimer testing in cardiovascular conditions.

April 19, 2026Kardiologia PolskaOpen Access

D-dimer testing in cardiovascular disease: Laboratory and clinical pitfalls

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This overview reveals pitfalls in D-dimer testing impacting cardiovascular disease evaluation, suggesting careful interpretation is necessary.

To summarize the challenges and clinical significance of D-dimer testing in cardiovascular conditions.
Review of laboratory practices and clinical outcomes related to D-dimer testing.
Analysis of factors affecting D-dimer assay results, including different assay methods and preanalytical variables.
Examination of the implications of elevated D-dimer levels in various cardiovascular diseases.
D-dimer test results vary significantly across different assays and laboratories.
Elevated D-dimer is associated with both acute and chronic cardiovascular conditions, indicating the need for cautious interpretation.
High negative predictive value of age-adjusted D-dimer for ruling out venous thromboembolism.

Sztefko et al. (2026) studied this question.

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This overview reveals pitfalls in D-dimer testing impacting cardiovascular disease evaluation, suggesting careful interpretation is necessary.