Completion vs . early discontinuation of chemotherapy and the impact on 5‐year all‐cause mortality in women treated for early‐stage breast cancer from 2015 to 2020: A cohort study using a target trial emulation approach

Q: What does this research mean for the field?

Completing six or more cycles of chemotherapy improves overall survival in women treated for early-stage breast cancer compared to those who discontinue treatment early. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Luke Steventon; Chengsheng Ju; Kenneth K. C. Man; R. Roylance; Diego Ottaviani; Chiara Creed; Michal Sladkowski; Alec Wisner; L. Wei; Pinkie Chambers

doi:10.1002/bcp.70488

March 8, 2026British Journal of Clinical PharmacologyOpen Access

Completion vs . early discontinuation of chemotherapy and the impact on 5‐year all‐cause mortality in women treated for early‐stage breast cancer from 2015 to 2020: A cohort study using a target trial emulation approach

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Key Points

To assess the impact of chemotherapy completion versus early discontinuation on 5-year mortality in women with early-stage breast cancer.
Cohort study design
Analysis of patients treated for early-stage breast cancer from 2015 to 2020
Focus on chemotherapy cycles of six or more
Patients completing six or more chemotherapy cycles showed improved overall survival compared to those who discontinued early.
Findings suggest a need for strategies to manage patients at risk of premature discontinuation.

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Implication

Cohort study evaluates impact of chemotherapy completion on mortality in women with breast cancer, indicating improved outcomes.

Abstract

Patients who completed greater than or equal to six cycles showed improved OS compared with those who discontinued before receiving six cycles. These findings support the identification and pre-emptive management of patients at high risk of discontinuing chemotherapy prematurely, to maximize treatment benefit.

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Cite This Study

Steventon et al. (2026) studied this question.

synapsesocial.com/papers/69b257ec96eeacc4fcec7153 https://doi.org/10.1002/bcp.70488

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Completion vs . early discontinuation of chemotherapy and the impact on 5‐year all‐cause mortality in women treated for early‐stage breast cancer from 2015 to 2020: A cohort study using a target trial emulation approach

Key Points

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Implication

Abstract

Discussion

Cite This Study

Completion vs . early discontinuation of chemotherapy and the impact on 5‐year all‐cause mortality in women treated for early‐stage breast cancer from 2015 to 2020: A cohort study using a target trial emulation approach

Key Points

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Implication

Abstract

Discussion

Cite This Study

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