Key result
Seizures, comorbidities, and absent fever linked to up to ~640% higher adverse outcome risk in pediatric enterovirus meningitis.
Why the study?
Non-polio enteroviruses are the most common cause of meningitis in children, but data on long-term outcomes were needed to guide post-discharge counseling and care pathways.
What are the risk factors for adverse long-term outcomes in children with enterovirus meningitis?
What are the risk factors for adverse long-term outcomes in children with enterovirus meningitis?
In children with enterovirus meningitis, absence of fever, seizures, and baseline comorbidities are risk factors for adverse outcomes, though the vast majority of infants under 3 months achieve full recovery.
Answers are grounded in this paper and cite their sources.
May warrant enhanced surveillance in high-risk enterovirus meningitis cases; extends prior observational data but remains hypothesis-generating.
Non-polio enteroviruses (EV) are the most common cause of meningitis in children. We conducted a retrospective case series of long-term outcomes in 243 children between 1/1/2013 and 31/12/2023 across four tertiary centres in London. Adverse outcomes were associated with absence of fever at presentation (odds ratio, OR 4.65, 95% CI 1.03, 20.83), presence of seizures (OR 7.40, 95% CI 1.05, 51.96) and presence of comorbidities at baseline (OR 5.27, 95% CI 1.18, 23.47). Full recovery was seen in 153/160 (95.6%) of children who were under 3 months of age. These data may help clinicians to counsel parents and policymakers on streamlining care pathways following hospital discharge.
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Broad et al. (2026) studied this question. Adverse outcomes in children with enterovirus meningitis were associated with absence of fever (OR 4.65), seizures (OR 7.40), and comorbidities (OR 5.27).
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