Key result
In neonates with enterovirus or parechovirus meningitis, those with pathological brain MRI scored significantly lower on the cognitive Bayley III subscale at 12 months compared to those with normal MRI, although scores remained within the normal range.
Why the study?
Data on the neurodevelopmental outcome of children who contract enterovirus meningitis in early childhood remain limited.
Population
30 term neonates with enterovirus and parechovirus meningitis contracted within the first month of life
Design
Longitudinal cohort study
Follow-up
Up to 12 months old
Authors
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May prompt enhanced developmental surveillance in neonates with abnormal MRI after viral meningitis; hypothesis-generating for prognostic utility.
Cohort (n=30)
No
Absolute Event Rate: 100.56% vs 109.55%
p-value: p=0.022
Early enterovirus and parechovirus meningitis in neonates is associated with brain MRI abnormalities, which correlate with lower cognitive scores at 12 months of age despite remaining within the normal range.
Bucci et al. (2022) conducted a cohort in Enterovirus and parechovirus meningitis (n=30). Pathological brain MRI during viral meningitis vs. Normal brain MRI was evaluated on Bayley III cognitive scale score at 12 months (p=0.022). In neonates with enterovirus or parechovirus meningitis, those with pathological brain MRI scored significantly lower on the cognitive Bayley III subscale at 12 months compared to those with normal MRI, although scores remained within the normal range.
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