Key result
At a median age of 18 months, 48.3% of infants with prior enterovirus CNS infection and 20% with parechovirus CNS infection presented some developmental concern in the ASQ-3 test.
Why the study?
Enteroviruses and human parechoviruses cause central nervous system infections in young infants and are implicated in neurodevelopmental delay, but limited data are available.
Observational (n=48)
Yes
Absolute Event Rate: 48.3% vs 20%
p-value: p=0.068
Infants with EV and HPeV CNS infections without encephalitis have a notable rate of medium-term neurodevelopmental concerns, particularly in communication for EV infections.
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Suggests developmental surveillance after infant EV/HPeV CNS infection; leaves open need for prospective studies before changing practice.
Ceano-Vivas et al. (2021) conducted an observational in Enterovirus and Parechovirus Infections of the Central Nervous System (n=48). Enterovirus (EV) CNS infection vs. Parechovirus (HPeV) CNS infection was evaluated on Developmental concern in the ASQ-3 test at first assessment (p=0.068). At a median age of 18 months, 48.3% of infants with prior enterovirus CNS infection and 20% with parechovirus CNS infection presented some developmental concern in the ASQ-3 test.
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