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March 12, 2026BiomedicinesOpen Access

Micro- and Macro-Vascular Disease in Systemic Sclerosis and Very Early SSc (VEDOSS): Results from a Monocentric Observational Study

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Authors

VZVincenzo ZacconeSCS. ContegiacomoSASilvia Agarbati

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Overview

This observational study identifies macrovascular disease in very early systemic sclerosis, suggesting improved risk assessment methods.

Key Points

  • To investigate micro- and macrovascular disease features in systemic sclerosis (SSc) and very early SSc (VEDOSS).
  • Cross-sectional study design
  • Participants included those with SSc, VEDOSS, and primary Raynaud’s phenomenon
  • Comprehensive assessments of microvascular and macrovascular health
  • Evaluated using nailfold videocapillaroscopy and arterial Doppler ultrasound
  • Measured endothelial biomarkers like VCAM-1 and ICAM-1
  • Microvascular abnormalities were seen in 57% of VEDOSS and 91% of SSc patients.
  • Macrovascular abnormalities were detected in 52.9% of SSc and 50% of VEDOSS participants, compared to 21.4% in PRP.
  • Levels of VCAM-1, ICAM-1, and circulating endothelial cells were significantly higher in SSc than in PRP.

Cite This Study

Zaccone et al. (2026) studied this question.

synapsesocial.com/papers/69b2582a96eeacc4fcec7815https://doi.org/10.3390/biomedicines14030607
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