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Decoding vascular dysfunction in systemic sclerosis: from endothelial damage to clinical implications

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Vascular dysfunction drives disease progression in systemic sclerosis, leading to complications like pulmonary arterial hypertension.
Endothelial injury and transition to different cell types are critical to understanding systemic sclerosis vasculopathy and its clinical impact.
Recent advances in molecular profiling have revealed distinct endothelial cell subtypes and dysregulated pathways in systemic sclerosis.
Emerging therapies, including CAR-T therapy and JAK inhibitors, seek to address the ongoing challenges in managing vascular dysfunction.

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This review explores vascular dysfunction and endothelial injury in systemic sclerosis, suggesting new therapeutic strategies.

Massay et al. (2025) studied this question.

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