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July 21, 2025BiomedicinesOpen Access

Systemic Sclerosis: A Key Model of Endothelial Dysfunction

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Authors

VZVincenzo ZacconeLFLorenzo FalsettiSCS. Contegiacomo

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Overview

This narrative review highlights the role of endothelial dysfunction in vascular injury in systemic sclerosis, suggesting new therapeutic strategies.

Key Points

  • Endothelial dysfunction is central to the vascular injury seen in systemic sclerosis, contributing to the disease's progression.
  • Persistent oxidative stress and autoimmunity lead to impaired endothelial function, fueling fibrosis and organ remodeling.
  • Impaired angiogenesis and diminished endothelial progenitor cell function disrupt vascular homeostasis, worsening clinical outcomes.
  • Recognizing systemic sclerosis as a model of endothelial dysfunction may shift therapeutic approaches and identify new treatment targets.

Cite This Study

Zaccone et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd2dchttps://doi.org/10.3390/biomedicines13071771
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decoding vascular dysfunction in systemic sclerosis: from endothelial damage to clinical implications2025 · 10 citations
  2. 2Recent Insights into Cellular and Molecular Mechanisms of Defective Angiogenesis in Systemic Sclerosis2024 · 18 citations
  3. 3Vascular involvement in systemic sclerosis (scleroderma)2011 · 117 citations
  4. 4Endotheliopathy in systemic sclerosis: from endothelium-dependent vasodilation to the dysfunction of the vascular reserve, is the paradise lost?2025 · 6 citations
  5. 5A dynamic vascular–inflammatory–fibrotic loop in systemic sclerosis: an integrative immuno-vascular framework2026