What question did this study set out to answer?

To review the pathophysiological role of endothelial dysfunction and the progressive loss of vascular reserve across multiple organ systems in systemic sclerosis.

May 17, 2025Arthritis Research & TherapyOpen Access

Endotheliopathy in systemic sclerosis: from endothelium-dependent vasodilation to the dysfunction of the vascular reserve, is the paradise lost?

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Authors

GBGiulia Bandini SBSilvia Bellando-Randone MMMirko Manetti

Discussion

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Overview

Literature review demonstrates widespread vascular reserve impairment in systemic sclerosis, suggesting early detection provides a window of opportunity for reversible targeted therapies.

Key Points

To review the pathophysiological role of endothelial dysfunction and the progressive loss of vascular reserve across multiple organ systems in systemic sclerosis.
Synthesized published literature examining endothelial cell pathology and vascular tone regulation during stress conditions in systemic sclerosis.
Assessed clinical and physiological data evaluating vascular reserve across cardiac, pulmonary, renal, and splanchnic circulatory networks.
Loss of vascular tone control manifests early as Raynaud's phenomenon and drives failure of normal microvascular adaptation under physiological stress.
Vascular reserve impairment occurs across major organs, including reduced coronary flow reserve, exercise-induced pulmonary hypertension, absent post-protein renal hyperfiltration, and abnormal splanchnic postprandial responses.
Identification of early vascular reserve breakdown marks a potentially reversible disease phase that is more susceptible to targeted therapeutic strategies.

Cite This Study

Bandini et al. (2025) studied this question.

synapsesocial.com/papers/69df0fefacbf09c32e6141b4 https://doi.org/10.1186/s13075-025-03568-x

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May 17, 2025Arthritis Research & TherapyOpen Access

Endotheliopathy in systemic sclerosis: from endothelium-dependent vasodilation to the dysfunction of the vascular reserve, is the paradise lost?

View Full Paper

Ask AI

Bookmark

Authors

GBGiulia Bandini SBSilvia Bellando-Randone MMMirko Manetti

Discussion

Member takes

Overview

Literature review demonstrates widespread vascular reserve impairment in systemic sclerosis, suggesting early detection provides a window of opportunity for reversible targeted therapies.

Key Points

To review the pathophysiological role of endothelial dysfunction and the progressive loss of vascular reserve across multiple organ systems in systemic sclerosis.
Synthesized published literature examining endothelial cell pathology and vascular tone regulation during stress conditions in systemic sclerosis.
Assessed clinical and physiological data evaluating vascular reserve across cardiac, pulmonary, renal, and splanchnic circulatory networks.
Loss of vascular tone control manifests early as Raynaud's phenomenon and drives failure of normal microvascular adaptation under physiological stress.
Vascular reserve impairment occurs across major organs, including reduced coronary flow reserve, exercise-induced pulmonary hypertension, absent post-protein renal hyperfiltration, and abnormal splanchnic postprandial responses.
Identification of early vascular reserve breakdown marks a potentially reversible disease phase that is more susceptible to targeted therapeutic strategies.

Cite This Study

Bandini et al. (2025) studied this question.

synapsesocial.com/papers/69df0fefacbf09c32e6141b4 https://doi.org/10.1186/s13075-025-03568-x

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