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November 1, 2000Current Opinion in Rheumatology

Vascular dysfunction in systemic sclerosis is widespread, affecting large and small vessels, and results from an interdependent imbalance of vasodilation and vasoconstriction leading to ischemic atrophy.

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Population

Patients with systemic sclerosis

Design

Review

Authors

AHAriane L. Herrick

Discussion

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Overview

May inform vascular monitoring in systemic sclerosis; leaves open targeted therapies for prospective validation.

Structured PICO

P
Population
Patients with systemic sclerosis

This review highlights that vascular dysfunction in systemic sclerosis is widespread and involves both structural and functional abnormalities leading to ischemic atrophy.

Cite This Study

Ariane L. Herrick (2000) studied this question.

synapsesocial.com/papers/6a834409b95cf4e61630e234https://doi.org/10.1097/00002281-200011000-00009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decoding vascular dysfunction in systemic sclerosis: from endothelial damage to clinical implications2025 · 10 citations
  2. 2Assessing digital vasculopathy in systemic sclerosis2026 · 1 citations
  3. 3Vascular involvement in systemic sclerosis (scleroderma)2011 · 117 citations
  4. 4Endotheliopathy in systemic sclerosis: from endothelium-dependent vasodilation to the dysfunction of the vascular reserve, is the paradise lost?2025 · 6 citations
  5. 5Systemic Sclerosis: A Key Model of Endothelial Dysfunction2025