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January 1, 2020Advances in Dermatology and AllergologyOpen Access

Patients with systemic sclerosis had a 45% lower relative increase of FMD and 13% higher IMT (p < 0.01 for both) compared to controls, along with increased thrombomodulin levels after adjustment (p = 0.03).

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Why the study?

Patients with systemic sclerosis experience endothelial dysfunction and damage even without clinical manifestations, prompting evaluation of methods to assess endothelial function in clinical practice.

Do patients with systemic sclerosis exhibit worse endothelial function compared to matched controls?

Comparison

Patients with systemic sclerosis vs matched controls

Design

Case-control study

Authors

RPRenata Pacholczak‐MadejPKPiotr KuszmierszSBStanisława Bazan‐Socha

Discussion

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Overview

Ultrasonography detects endothelial dysfunction in systemic sclerosis; leaves open its clinical utility or prognostic value.

Structured PICO

Do patients with systemic sclerosis exhibit worse endothelial function compared to matched controls?

P
Population
42 patients (7 men, 35 women) with systemic sclerosis and 36 controls (11 men, 25 women) matched for age, sex, body mass index, smoking habit, and comorbidities.
C
Comparator
Matched controls
O
Outcome
Endothelial function assessed by serum VCAM-1, thrombomodulin, flow-mediated dilatation (FMD) of the brachial artery, and intima-media thickness (IMT) of the common carotid arterysurrogate

Patients with systemic sclerosis exhibit significant endothelial dysfunction, detectable via ultrasonographic methods like FMD and IMT, compared to matched controls.

Cite This Study

Pacholczak‐Madej et al. (2020) studied this question.

synapsesocial.com/papers/6a712afa31a3df8243296185https://doi.org/10.5114/ada.2019.83501
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial dysfunction precedes atherosclerosis in systemic sclerosis--relevance for prevention of vascular complications2007 · 139 citations
  2. 2Flow‐Mediated Vasodilation and Carotid Intima‐Media Thickness in Systemic Sclerosis2007 · 84 citations
  3. 3Silent cardiovascular involvement in patients with diffuse systemic sclerosis: a controlled cross‐sectional study2012 · 44 citations
  4. 4Associations Between Left Ventricular Myocardial Involvement and Endothelial Dysfunction in Systemic Sclerosis: Noninvasive Assessment in Asymptomatic Patients2007 · 35 citations
  5. 5Effect of Vasodilator And Immunosuppressive Therapy On The Endothelial Dysfunction In Patients With Systemic Sclerosis2021