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July 16, 2003British journal of rheumatology

Carotid and femoral arterial wall mechanics in scleroderma

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Why the study?

Are the biomechanical properties and intima-media thickness of the carotid and femoral arteries altered in patients with scleroderma compared to controls?

Population

73 subjects, including 33 patients with limited cutaneous scleroderma, 19 patients with diffuse cutaneous…

Comparison

Scleroderma vs Control subjects without scleroderma

Design

Cross-sectional

Authors

KCKathleen Cheng

Discussion

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Overview

Reduced carotid compliance in SSc may signal subclinical vasculopathy; leaves open its prognostic value and therapeutic implications.

Structured PICO

Are the biomechanical properties and intima-media thickness of the carotid and femoral arteries altered in patients with scleroderma compared to controls?

P
Population
73 subjects, including 33 patients with limited cutaneous scleroderma (lcSSc), 19 patients with diffuse cutaneous scleroderma (dcSSc), and 21 control subjects.
I
Intervention
Scleroderma (limited and diffuse cutaneous systemic sclerosis)
C
Comparator
Control subjects without scleroderma
O
Outcome
Biomechanical properties (elastic properties) and intima-media thickness (IMT) of the carotid and femoral arteriessurrogate

Scleroderma is associated with significantly reduced carotid artery elasticity, which worsens with disease severity, suggesting connective tissue abnormalities in large vessels not clinically involved.

Cite This Study

Kathleen Cheng (2003) studied this question.

synapsesocial.com/papers/6a720c0022b3175134db6da1https://doi.org/10.1093/rheumatology/keg371
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Also Consider

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  1. 1Flow‐Mediated Vasodilation and Carotid Intima‐Media Thickness in Systemic Sclerosis2007 · 84 citations
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  4. 4Microvascular damage is associated with carotid wall structural changes in Systemic Sclerosis: a capillaroscopy and ultrasound‐based observational study2026
  5. 5Silent cardiovascular involvement in patients with diffuse systemic sclerosis: a controlled cross‐sectional study2012 · 44 citations