Key result
Women with systemic sclerosis had a higher aortic augmentation index (30.9% vs 22.2%; P=0.012) and lower pulse pressure amplification than matched healthy controls.
Why the study?
Does systemic sclerosis alter central hemodynamics and arterial stiffness compared to healthy matched controls?
Population
34 women with systemic sclerosis and 34 healthy women individually matched by age and mean arterial pressure.
Comparison
Assessment of central hemodynamics and arterial… vs Healthy women individually matched by age and…
Design
Case-control
Authors
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May signal early central hemodynamic alterations in systemic sclerosis; hypothesis-generating for vascular progression and outcomes.
Case-Control (n=68)
Does systemic sclerosis alter central hemodynamics and arterial stiffness compared to healthy matched controls?
Absolute Event Rate: 30.9% vs 22.2%
p-value: p=0.012
Women with systemic sclerosis exhibit increased aortic augmentation and decreased pulse pressure amplification, suggesting that microvascular involvement occurs earlier than large artery stiffening.
Bartoloni et al. (2016) conducted a case-control in Systemic Sclerosis (n=68). Systemic sclerosis vs. Healthy controls was evaluated on Aortic augmentation index corrected for a heart rate of 75 bpm (AIx@75) (p=0.012). Women with systemic sclerosis had a higher aortic augmentation index (30.9% vs 22.2%; P=0.012) and lower pulse pressure amplification than matched healthy controls.
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