Why the study?
Do patients with diffuse systemic sclerosis without clinical cardiovascular disease have evidence of subclinical atherosclerosis and endothelial dysfunction compared to healthy controls?
Population
20 patients with diffuse systemic sclerosis who had no signs or symptoms of cardiovascular disease and 20…
Comparison
Diffuse systemic sclerosis (exposure) vs Age- and sex-matched healthy controls
Design
Cross-sectional
Key result
Diffuse systemic sclerosis was associated with subclinical atherosclerosis, evidenced by significantly lower coronary flow reserve (P=0.0033) and higher plasma ADMA levels (P<0.0001) versus controls.
Authors
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Subclinical atherosclerosis markers in asymptomatic diffuse SSc warrant caution in risk assessment; leaves open need for prospective outcome studies.
Cross-Sectional (n=40)
Do patients with diffuse systemic sclerosis without clinical cardiovascular disease have evidence of subclinical atherosclerosis and endothelial dysfunction compared to healthy controls?
p-value: p=0.0033 for CFR, <0.0001 for ADMA
Patients with diffuse systemic sclerosis without clinical cardiovascular disease exhibit signs of subclinical atherosclerosis, including impaired coronary microcirculation and macrovascular involvement.
Turiel et al. (2012) conducted a cross-sectional in Diffuse systemic sclerosis (n=40). Diffuse systemic sclerosis vs. Age- and sex-matched healthy controls was evaluated on Coronary flow reserve, carotid intima-media thickness, arterial stiffness, and plasma ADMA levels (p=0.0033 for CFR, <0.0001 for ADMA). Diffuse systemic sclerosis was associated with subclinical atherosclerosis, evidenced by significantly lower coronary flow reserve (P=0.0033) and higher plasma ADMA levels (P<0.0001) versus controls.
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