Why the study?
Does systemic sclerosis reduce endothelium-dependent flow-mediated dilatation in patients compared to healthy controls?
Population
29 patients with systemic sclerosis and 29 healthy controls matched for sex, age, and traditional…
Comparison
Systemic sclerosis (disease state) vs Healthy controls
Design
Case-control
Authors
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SSc was associated with reduced FMD indicating early endothelial dysfunction; hypothesis-generating for vascular assessment, requires prospective confirmation before practice change.
Does systemic sclerosis reduce endothelium-dependent flow-mediated dilatation in patients compared to healthy controls?
Systemic sclerosis is associated with impaired endothelium-dependent vasodilatation (low FMD) that precedes overt atherosclerosis, highlighting a potential window for early vascular assessment and intervention.
Szűcs et al. (2007) studied this question.
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