Why the study?
Does systemic sclerosis increase subclinical atherosclerosis as measured by FMD and IMT compared to healthy controls?
Population
35 patients with systemic sclerosis and 20 healthy controls.
Comparison
Systemic sclerosis (disease state) vs Healthy controls
Design
Case-control
Key result
Systemic sclerosis was associated with impaired flow-mediated vasodilation (3.41% vs 7.66%; P<0.037) and increased carotid intima-media thickness (0.93 vs 0.77 mm; P<0.005) versus healthy controls.
Authors
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SSc patients exhibit impaired FMD and increased IMT independent of traditional risks; leaves open whether these changes warrant routine macrovascular screening or predict outcomes.
Case-Control (n=55)
Does systemic sclerosis increase subclinical atherosclerosis as measured by FMD and IMT compared to healthy controls?
Absolute Event Rate: 3.41% vs 7.66%
p-value: p=<0.037
Systemic sclerosis is associated with impaired endothelial function and increased carotid intima-media thickness, indicating accelerated subclinical atherosclerosis independent of traditional risk factors.
Bartoli et al. (2007) conducted a case-control in Systemic sclerosis (n=55). Systemic sclerosis vs. Healthy controls was evaluated on Brachial artery flow-mediated vasodilation (FMD) (p=<0.037). Systemic sclerosis was associated with impaired flow-mediated vasodilation (3.41% vs 7.66%; P<0.037) and increased carotid intima-media thickness (0.93 vs 0.77 mm; P<0.005) versus healthy controls.
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