Why the study?
The authors sought to assess subclinical atherosclerosis in spondyloarthritis by combining three ultrasound methods (FMD, cIMT, and ABI) and to determine predictive factors for these parameters.
Does spondyloarthritis increase markers of subclinical atherosclerosis in patients without cardiovascular disease compared to healthy controls?
Population
47 patients with SpA free of CV disease and 47 age- and sex-matched healthy controls
Comparison
SpA patients vs healthy controls
Design
Case-control study
Key result
Patients with spondyloarthritis had higher carotid intima-media thickness (p<0.0001) and lower flow-mediated dilation (p=0.008) compared to healthy controls.
Authors
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SpA patients showed elevated subclinical atherosclerosis markers; supports CV risk vigilance but leaves open whether ultrasound screening improves outcomes.
Case-Control (n=94)
Does spondyloarthritis increase markers of subclinical atherosclerosis in patients without cardiovascular disease compared to healthy controls?
p-value: p=<0.0001
Patients with spondyloarthritis exhibit accelerated subclinical atherosclerosis, as evidenced by increased cIMT and decreased FMD, which appears to be mediated by traditional cardiovascular risk factors.
Tekaya et al. (2022) conducted a case-control in Spondyloarthritis (n=94). Spondyloarthritis vs. Healthy controls was evaluated on Subclinical atherosclerosis assessed by carotid intima-media thickness (cIMT), flow-mediated dilation (FMD), and Ankle Brachial Index (ABI) (p=<0.0001). Patients with spondyloarthritis had higher carotid intima-media thickness (p<0.0001) and lower flow-mediated dilation (p=0.008) compared to healthy controls.
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