What is the clinical evidence from this study?

Study design: Observational. Population: Systemic sclerosis (n=39). Intervention: Systemic sclerosis vs. Healthy controls. Primary outcome: Mean coronary flow reserve (CFR) (p=<0.001).

January 1, 2015Circulation JournalOpen Access

Coronary Microvascular Dysfunction in Asymptomatic Patients Affected by Systemic Sclerosis – Limited vs. Diffuse Form –

Q: What are the key findings of this study?

Asymptomatic patients with systemic sclerosis had significantly lower mean coronary flow reserve compared to healthy controls (1.96 vs 2.69, P<0.001), indicating a high prevalence of coronary microvascular dysfunction.

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Key result

Asymptomatic patients with systemic sclerosis had significantly lower mean coronary flow reserve compared to healthy controls (1.96 vs 2.69, P<0.001), indicating a high prevalence of coronary microvascular dysfunction.

Why the study?

Does systemic sclerosis (diffuse vs limited forms) impair coronary flow reserve in asymptomatic patients compared to healthy controls?

Population

19 consecutive asymptomatic patients with systemic sclerosis and 20 healthy controls.

Design

Cross-sectional

Authors

AFAlessia Faccini EAEustachio Agricola MOMichele Oppizzi

Discussion

Member takes

Overview

May support evaluation for coronary microvascular dysfunction in asymptomatic systemic sclerosis; hypothesis-generating and requires prospective validation.

Study Design

Type

Observational (n=39)

Multicenter

Structured PICO

Does systemic sclerosis (diffuse vs limited forms) impair coronary flow reserve in asymptomatic patients compared to healthy controls?

Population

19 asymptomatic patients with systemic sclerosis and 20 healthy controls, aged 18 to 75 years, underwent dipyridamole stress echocardiography to assess coronary microvascular dysfunction.

Comparator

Healthy controls (n=20)

Outcome

Coronary flow reserve (CFR) and prevalence of abnormal CFR (≤2)surrogate

Main Result

Absolute Event Rate: 1.96% vs 2.69%

p-value: p=<0.001

Asymptomatic patients with systemic sclerosis, particularly the diffuse form, have a high prevalence of coronary microvascular dysfunction as evidenced by blunted coronary flow reserve.

Limitations

Patients and controls were not age matched.
Coronary angiography was not performed in patients with reduced CFR to definitively exclude epicardial stenosis.
Small sample size leading to borderline statistical significance in subgroup analyses.
All patients came from a single clinical center, introducing potential selection bias.

Cite This Study

Faccini et al. (2015) conducted an observational in Systemic sclerosis (n=39). Systemic sclerosis vs. Healthy controls was evaluated on Mean coronary flow reserve (CFR) (p=<0.001). Asymptomatic patients with systemic sclerosis had significantly lower mean coronary flow reserve compared to healthy controls (1.96 vs 2.69, P<0.001), indicating a high prevalence of coronary microvascular dysfunction.

synapsesocial.com/papers/6ab7465a2d732561aafb8a15 https://doi.org/10.1253/circj.cj-14-1114

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January 1, 2015Circulation JournalOpen Access

Coronary Microvascular Dysfunction in Asymptomatic Patients Affected by Systemic Sclerosis – Limited vs. Diffuse Form –

View Full Paper

Ask AI

Bookmark

Key result

Why the study?

Does systemic sclerosis (diffuse vs limited forms) impair coronary flow reserve in asymptomatic patients compared to healthy controls?

Population

19 consecutive asymptomatic patients with systemic sclerosis and 20 healthy controls.

Design

Cross-sectional

Authors

AFAlessia Faccini EAEustachio Agricola MOMichele Oppizzi

Discussion

Member takes

Overview

May support evaluation for coronary microvascular dysfunction in asymptomatic systemic sclerosis; hypothesis-generating and requires prospective validation.

Study Design

Type

Observational (n=39)

Multicenter

Structured PICO

Does systemic sclerosis (diffuse vs limited forms) impair coronary flow reserve in asymptomatic patients compared to healthy controls?

Population

19 asymptomatic patients with systemic sclerosis and 20 healthy controls, aged 18 to 75 years, underwent dipyridamole stress echocardiography to assess coronary microvascular dysfunction.

Comparator

Healthy controls (n=20)

Outcome

Coronary flow reserve (CFR) and prevalence of abnormal CFR (≤2)surrogate

Main Result

Absolute Event Rate: 1.96% vs 2.69%

p-value: p=<0.001

Asymptomatic patients with systemic sclerosis, particularly the diffuse form, have a high prevalence of coronary microvascular dysfunction as evidenced by blunted coronary flow reserve.

Limitations

Patients and controls were not age matched.
Coronary angiography was not performed in patients with reduced CFR to definitively exclude epicardial stenosis.
Small sample size leading to borderline statistical significance in subgroup analyses.
All patients came from a single clinical center, introducing potential selection bias.

Cite This Study

synapsesocial.com/papers/6ab7465a2d732561aafb8a15 https://doi.org/10.1253/circj.cj-14-1114

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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