What question did this study set out to answer?

To determine whether cardiovascular magnetic resonance (CMR) can identify early cardiac pathophysiology in patients with asymptomatic diffuse systemic sclerosis.

September 16, 2015Inflammation & Allergy - Drug Targets

Cardiovascular Magnetic Resonance Imaging clarifies cardiac pathophysiology in early, asymptomatic diffuse systemic sclerosis

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To determine whether cardiovascular magnetic resonance (CMR) can identify early cardiac pathophysiology in patients with asymptomatic diffuse systemic sclerosis.
Evaluated 46 recently diagnosed, asymptomatic patients with diffuse systemic sclerosis using 1.5T CMR with cine and T2 STIR imaging.
Assigned patients based on T2 ratio to either a stress perfusion-fibrosis protocol (T2 < 2) or a myocarditis protocol with early and late gadolinium imaging (T2 > 2).
Compared imaging markers against matched healthy controls and coronary artery disease (CAD) patients, including a 2-year follow-up in 11 patients.
In 2 of 46 patients (T2 ratio > 2), CMR detected acute myocardial inflammation, and both patients rapidly developed clinical acute myocarditis.
In 44 of 46 patients (T2 ratio < 2), Myocardial Perfusion Reserve Index was significantly reduced compared to controls (0.6 ± 0.4 vs 3.2 ± 0.8, p < 0.001) but comparable to CAD (0.6 ± 0.4 vs 0.86 ± 0.46, p=NS).
At 2-year follow-up (n=11), all patients showed further asymptomatic deterioration of myocardial perfusion, and 8 of 11 developed diffuse subendocardial late gadolinium enhancement despite stable ventricular function.

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Implication

Observational study reveals severe occult myocardial perfusion defects and fibrosis in early asymptomatic diffuse systemic sclerosis, highlighting silent cardiac involvement.

Cite This Study

Mavrogeni et al. (2015) studied this question.

synapsesocial.com/papers/6a7245deb5c1fe5ca9dff7e0 https://doi.org/10.2174/1871528114666150916112551

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Implication

Observational study reveals severe occult myocardial perfusion defects and fibrosis in early asymptomatic diffuse systemic sclerosis, highlighting silent cardiac involvement.

Cardiovascular Magnetic Resonance Imaging clarifies cardiac pathophysiology in early, asymptomatic diffuse systemic sclerosis

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Discussion

Implication

Cite This Study

Cardiovascular Magnetic Resonance Imaging clarifies cardiac pathophysiology in early, asymptomatic diffuse systemic sclerosis

Key Points

Discussion

Implication

Cite This Study

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