September 4, 2014European Heart Journal - Cardiovascular Imaging
Early myocardial and skeletal muscle interstitial remodelling in systemic sclerosis: insights from extracellular volume quantification using cardiovascular magnetic resonance
Why the study?
Does CMR-derived extracellular volume (ECV) quantification detect subclinical myocardial and skeletal muscle interstitial remodelling in paucisymptomatic systemic sclerosis patients compared to healthy controls?
Structured PICO
Does CMR-derived extracellular volume (ECV) quantification detect subclinical myocardial and skeletal muscle interstitial remodelling in paucisymptomatic systemic sclerosis patients compared to healthy controls?
P
Population
30 consecutive female patients with systemic sclerosis (SSc), mean age 51 ± 12 years, paucisymptomatic with no previous history of myocardial disease (17 asymptomatic, 13 with effort dyspnoea).
I
Intervention
Cardiovascular magnetic resonance (CMR) with T1 mapping for extracellular volume fraction (ECV) quantification
C
Comparator
10 healthy female controls, mean age 48 ± 15 years
O
Outcome
Myocardial and skeletal muscle extracellular volume fraction (ECV)surrogate
CMR-derived ECV quantification can detect subclinical interstitial remodelling in both myocardium and skeletal muscle in paucisymptomatic systemic sclerosis patients with normal biventricular function.
Authors
Discussion
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Implication
May support ECV for detecting subclinical remodelling in SSc; hypothesis-generating and should not yet change practice.
Cite This Study
Barison et al. (2014) studied this question.