Extracellular volume fraction quantification at cardiac MR imaging revealed significantly higher global ECV in systemic sclerosis patients compared to healthy controls (P < .001).
Observational (n=49)
Does extracellular volume fraction (ECV) quantification with cardiac MR imaging identify subclinical left ventricle abnormalities in systemic sclerosis patients?
ECV quantification by cardiac MRI can detect early, subclinical left ventricular abnormalities reflecting diffuse myocardial fibrosis in systemic sclerosis patients with normal echocardiograms.
p-value: p=< .001
PURPOSE: To determine whether extracellular volume fraction (ECV) quantification at cardiac magnetic resonance (MR) imaging can demonstrate subclinical left ventricle (LV) abnormalities in a cohort of consecutive systemic sclerosis (SS) patients, and to investigate the relationship between ECV and diastolic and systolic LV function. MATERIALS AND METHODS: All subjects gave their written informed consent. The protocol was approved by the ethics committee. ECV quantification with cardiac MR imaging was prospectively performed in 33 consecutive SS patients with normal echocardiography results and no late gadolinium chelate enhancement at MR imaging. Left ventricular and atrial volumes and peak circumferential strain were measured at cardiac MR imaging. Diastolic function was assessed at echocardiography. The results were compared with those of 16 age-matched healthy control subjects by using Mann-Whitney and Kruskal-Wallis tests. RESULTS: SS patients had significantly higher global ECV (P < .001) and higher local ECV for all basal and midventricular LV segments. Global ECV significantly correlated with left atrial volume (P = .002) and with the grade of diastolic dysfunction (P = .016). The majority of SS patients (63%; 21 of 33 patients) had a high global ECV and a low global systolic circumferential strain. CONCLUSION: ECV quantification can identify LV abnormalities at an early stage in SS patients. These abnormalities may reflect increase in diffuse myocardial fibrosis and are associated with diastolic LV dysfunction.
Thuny et al. (Wed,) conducted a observational in Systemic sclerosis (n=49). Extracellular volume fraction (ECV) quantification at cardiac MR imaging vs. Age-matched healthy control subjects was evaluated on Global extracellular volume fraction (ECV) (p=< .001). Extracellular volume fraction quantification at cardiac MR imaging revealed significantly higher global ECV in systemic sclerosis patients compared to healthy controls (P < .001).