What question did this study set out to answer?

This study aims to evaluate the cardiovascular phenotypes in systemic sclerosis (SSc) patients using cardiac magnetic resonance (CMR) imaging.

Cardiac Involvement in Systemic Sclerosis Beyond the Right Heart: Novel and Conventional Cardiac Magnetic Resonance Phenomics-Based Evaluation

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Randomized trial investigates cardiac outcomes in systemic sclerosis, highlighting the need for advanced CMR evaluation.

This study aims to evaluate the cardiovascular phenotypes in systemic sclerosis (SSc) patients using cardiac magnetic resonance (CMR) imaging.
100 SSc patients and 100 healthy volunteers were studied using conventional and advanced CMR techniques.
Patients underwent CMR imaging including cine and late gadolinium enhancement (LGE) to assess cardiomyopathy and compare metrics.
Analysis included conventional CMR markers and advanced 4Deep modeling to assess left ventricular (LV) function and structure.
30% of SSc patients exhibited cardiomyopathy (21% with abnormal LVEF, 18% with abnormal LGE).
4Deep analysis showed SSc patients experienced a 14.7% reduction in LVEF and significant changes in LV wall thickness compared to healthy volunteers.
32% of SSc patients developed a composite primary outcome, with right ventricular ejection fraction (RVEF) as the only independent predictor (HR 0.95, p=0.006).

Nasir et al. (2026) studied this question.

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