An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of linezolid in human serum and plasma

Marie Kubicova; Neeraj Singh; Carina Schuster; Friederike Bauland; Andrea Geistanger; Michael Vogeser; Judith Taibon

doi:10.1515/cclm-2025-1366

March 9, 2026Clinical Chemistry and Laboratory Medicine (CCLM)Open Access

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of linezolid in human serum and plasma

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Key Points

This research aims to develop a reliable method for quantifying linezolid in human serum and plasma using LC-MS/MS techniques.
Developed a candidate reference measurement procedure (RMP) using isotope dilution and LC-MS/MS techniques.
Tested the method's performance on human serum and plasma samples.
Evaluated the method for analytical reliability and traceability.
The LC-MS/MS method provided accurate quantification of linezolid.
Demonstrated robust performance suitable for standardizing routine analytical assays.
Ensured reliability and traceability in individual patient sample analyses.

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Implication

Candidate reference measurement procedure quantifies linezolid in serum and plasma, ensuring reliability and traceability.

Abstract

This LC-MS/MS-based candidate RMP accurately quantifies linezolid in human serum and plasma. Its robust performance makes it suitable for standardization of routine analytical assays and for analysis of individual patient samples, ensuring analytical reliability and traceability.

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Kubicova et al. (2026) studied this question.

synapsesocial.com/papers/69b2582a96eeacc4fcec7843 https://doi.org/10.1515/cclm-2025-1366

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An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of linezolid in human serum and plasma

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of linezolid in human serum and plasma

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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