What question did this study set out to answer?

This study aims to validate a method for quantifying linezolid and its metabolites in non-invasive samples.

Simultaneous quantification of linezolid and its metabolites (PNU-142300 and PNU-142586) in oral fluid and capillary blood by UPLC-MS/MS: method validation and clinical application using non-invasive sampling techniques

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial investigates linezolid monitoring in non-invasive matrices, suggesting practical applications for therapeutic drug monitoring.

This study aims to validate a method for quantifying linezolid and its metabolites in non-invasive samples.
Developed a UPLC-MS/MS method validated according to ICH M10 guidelines.
Analyzed paired samples from 35 patients receiving linezolid.
Assessed linearity, accuracy, precision, and stability across oral fluid and capillary blood samples.
Assay demonstrated linearity from 0.1 to 5 µg/mL for all analytes across matrices.
LZD concentrations showed strong correlations with venous plasma in both VAMS and oral fluid.
Metabolites were rarely detectable in oral fluid, making monitoring limited to linezolid.

González-Berdullas et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Randomized trial investigates linezolid monitoring in non-invasive matrices, suggesting practical applications for therapeutic drug monitoring.