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To investigate the occurrence of serotonin syndrome due to chronic high-dose tramadol use.

March 12, 2026Toxicology ReportsOpen Access

Chronic tramadol abuse as a cause of serotonin syndrome

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To investigate the occurrence of serotonin syndrome due to chronic high-dose tramadol use.
Presented a case of a 22-year-old man with tramadol dependence.
Conducted a physical examination and laboratory investigations.
Utilized the Hunter Serotonin Toxicity Criteria for diagnosis.
Patient exhibited symptoms including anxiety, agitation, diaphoresis, and tachycardia.
Diagnosis of serotonin syndrome was confirmed based on clinical criteria.
Patient recovered completely within 48 hours after discontinuation of tramadol.

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A case report reveals serotonin syndrome from chronic tramadol use, highlighting clinical implications.

Gemert et al. (2026) studied this question.

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