Key result
A toxic overdose of tramadol alone resulted in clinical features suggestive of serotonin syndrome, including hallucinations and muscular twitching, which rapidly resolved upon discontinuation.
Case Report (n=1)
Tramadol overdose can cause serotonin syndrome even without the concomitant use of other serotonergic medications.
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Supports vigilance for serotonin syndrome in isolated tramadol overdose; leaves open incidence and therapeutic-dose risk.
Takeshita et al. (2009) conducted a case report in Serotonin syndrome (n=1). Tramadol overdose was evaluated on Development of serotonin syndrome. A toxic overdose of tramadol alone resulted in clinical features suggestive of serotonin syndrome, including hallucinations and muscular twitching, which rapidly resolved upon discontinuation.
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