What question did this study set out to answer?

The study aims to analyze how genetic variations in the ace-1 gene contribute to pesticide resistance in Anopheles sinensis.

March 12, 2026Infectious Diseases of Poverty0 citationsOpen Access

Heterogeneous duplication and point mutation of ace-1 confer organophosphates and carbamates resistance to Anopheles sinensis field populations in Guizhou Province, China

QXQiu-Qiu XiaoGuiyang Medical University WLWei LiBGI Group (China)QLQiu-Guo LiangQiannan Normal College For Nationalities

Key Points

The study aims to analyze how genetic variations in the ace-1 gene contribute to pesticide resistance in Anopheles sinensis.
Field sampling of An. sinensis populations in Guizhou Province
Genetic analysis to identify ace-1 gene duplications and mutations
Resistance testing against organophosphates and carbamates
Widespread resistance to organophosphates and carbamates in An. sinensis populations
Identification of heterogeneous duplication and point mutations in the ace-1 gene
Highlighting the need for monitoring of resistance alleles for effective management strategies

Abstract

Resistance to OPs and CBs is widespread in An. sinensis populations across Guizhou Province. Both heterogeneous duplication and point mutation of the ace-1 gene in An. sinensis likely contribute to resistance to OPs and CBs. These findings highlight the necessity of monitoring duplicated resistance alleles in natural populations to formulate region-specific resistance management strategies.

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