What does this research mean for the field?

Higher circulating erythroferrone levels are associated with an increased mortality risk in patients with chronic kidney disease. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to understand how erythroferrone relates to mortality risk and iron metabolism in chronic kidney disease (CKD) patients.

March 12, 2026Clinical Kidney JournalOpen Access

Erythroferrone is associated with the hepcidin-to-ferritin ratio and cardiovascular mortality in chronic kidney disease

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Authors

KPKristin Danielson PistisKarolinska Institutet AQAbdul Rashed QureshiKarolinska Institutet SBSoheir BesharaKarolinska Institutet

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Implication

Cross-sectional study assesses erythroferrone's link to mortality and iron levels in chronic kidney disease, suggesting implications for treatment.

Key Points

This research aims to understand how erythroferrone relates to mortality risk and iron metabolism in chronic kidney disease (CKD) patients.
Cross-sectional study with longitudinal follow-up.
Evaluated 377 CKD patients across stages 3-5.
Measured erythroferrone, hepcidin, ferritin, transferrin saturation, and C-reactive protein.
Analyzed associations using regression analyses and Fine-Gray analysis for mortality risk.
Erythroferrone and ferritin levels were higher in patients on peritoneal dialysis and CKD stage 5.
Erythroferrone positively correlated with reticulocyte count and negatively with transferrin saturation and hepcidin-to-ferritin ratio.
Higher erythroferrone linked to increased all-cause and cardiovascular mortality risk.

Cite This Study

Pistis et al. (2026) studied this question.

synapsesocial.com/papers/69b25aca96eeacc4fcec8d24 https://doi.org/10.1093/ckj/sfag075

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Implication

Cross-sectional study assesses erythroferrone's link to mortality and iron levels in chronic kidney disease, suggesting implications for treatment.

Erythroferrone is associated with the hepcidin-to-ferritin ratio and cardiovascular mortality in chronic kidney disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Erythroferrone is associated with the hepcidin-to-ferritin ratio and cardiovascular mortality in chronic kidney disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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