⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

March 10, 2026Biomarkers in Medicine

The Syn-sleep trial protocol: detection of cutaneous phosphorylated alpha-synuclein in REM sleep behavior disorder

Sarrah Marcotte Todd Levine R. Freeman C. Gibbons

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to investigate the frequency of phosphorylated alpha-synuclein deposition in patients with REM sleep behavior disorder (iRBD) and its impact on phenoconversion to synucleinopathy.
Defined the trial protocol for detecting phosphorylated alpha-synuclein
Focused on patients with idiopathic REM sleep behavior disorder (iRBD)
Assessed the relationship between α-synuclein deposition and risk of phenoconversion
Identified the frequency of cutaneous phosphorylated alpha-synuclein among participants
Highlighted the potential for α-synuclein deposition to indicate risk of developing synucleinopathies

Implication

Trial protocol examines phosphorylated alpha-synuclein in REM sleep behavior disorder, suggesting implications for clinical trials.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Marcotte et al. (2026) studied this question.

synapsesocial.com/papers/69b25b0996eeacc4fcec9548 https://doi.org/10.1080/17520363.2026.2641474

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The Syn-sleep Study: Detection of Cutaneous Phosphorylated Alpha-synuclein in REM Sleep Behavior Disorder (P9-14.001)Original Research · 2026
2The Syn-Q Study: Quantification of Phosphorylated Alpha-synuclein in Patients with Parkinson’s Disease and REM Sleep Behavior Disorder (P6-16.007)Original Research · 2026
3Presynaptic Dopaminergic Imaging Characterizes Patients with <scp>REM</scp> Sleep Behavior Disorder Due to Synucleinopathy2024 · 50 citations
4Advances in the Understanding of REM Sleep Behavior Disorder as a Biomarker for Neurodegenerative DiseasesReview · 2026
5Characterization of patients with isolated REM sleep behavior disorder and cerebrospinal fluid α-synuclein negativityOriginal Research · 2026