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This research investigates the relationship between choroid plexus enhancement and tissue injury in multiple sclerosis.

March 12, 2026Journal of Neuroimaging0 citations

Quantitative Choroid Plexus Gadolinium Enhancement Is Related to Diffuse Brain Tissue Injury in Multiple Sclerosis

SSSneha Senthil ITIan TaggeMontreal Neurological Institute and Hospital DFDumitru FetcoMontreal Neurological Institute and Hospital

Key Points

This research investigates the relationship between choroid plexus enhancement and tissue injury in multiple sclerosis.
Analyzed choroid plexus enhancement using gadolinium
Measured qT1 values and choroid plexus volumes
Examined tissue injury indicators in multiple sclerosis
Choroid plexus enhancement correlates with diffuse brain tissue injury
Elevated qT1 values support the presence of brain tissue damage
Changes in choroid plexus volume are observed in multiple sclerosis patients

Abstract

The association between ChP enhancement and diffuse tissue injury, together with elevated qT1 values and ChP volumes in MS, supports a mechanism of brain injury involving CSF-mediated toxicity distinct from classic lesion pathology in MS.

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