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March 12, 2026

Vitamin D Supplementation in Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials.

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Authors

DPDimitrios PapandreouSBS BaderKAKhaled Abass

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Overview

Systematic review evaluates vitamin D's effects on glycemic outcomes in type 2 diabetes, suggesting targeted supplementation.

Key Points

  • This review assesses the impact of vitamin D supplementation on glycemic control and metabolic parameters in individuals with type 2 diabetes or prediabetes.
  • Conducted a systematic review of randomized controlled trials (RCTs) up to March 2025.
  • Identified studies through searches of PubMed, Scopus, and Web of Science.
  • Performed data extraction and risk of bias assessment using Cochrane RoB 2 tool.
  • Thirty RCTs involving 2627 adults were included in the review.
  • Supplementation consistently increased serum 25(OH)D levels.
  • HbA1c and fasting blood glucose showed significant reductions in about half of the studies, especially in those with vitamin D deficiency.
  • Effects on HOMA-IR were mixed, with inconsistent changes in secondary outcomes like lipid profiles and blood pressure.

Cite This Study

Papandreou et al. (2026) studied this question.

synapsesocial.com/papers/69b25b7196eeacc4fceca3eahttps://doi.org/10.1080/19390211.2026.2636469
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Vitamin D Supplementation on Glycaemic Control in Type 2 Diabetes Patients: A Double Blind Randomized Controlled Trial2024 · 1 citations
  2. 2The Impact of Vitamin D Supplementation on Fasting Plasma Glucose, Insulin Sensitivity, and Inflammation in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis2025 · 12 citations
  3. 3Effect of Vitamin D Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Trial2024 · 4 citations
  4. 4Vitamin D supplementation of glycemic control in type 2 diabetes mellitus patients: a randomized controlled study2024 · 2 citations
  5. 5The Impact of Vitamin D in Primary Prevention of Type 2 Diabetes – A Systematic Review2025