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July 31, 2025NutrientsOpen Access

The Impact of Vitamin D Supplementation on Fasting Plasma Glucose, Insulin Sensitivity, and Inflammation in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

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Authors

EPEnny ProbosariDiponegoro UniversityHSHertanto Wahyu SubagioDiponegoro UniversityHHeri-NugrohoDr. Kariadi Hospital

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Implication

Systematic review reveals vitamin D supplementation improves insulin sensitivity and inflammation in type 2 diabetes, indicating its potential role in management.

Key Points

  • Vitamin D supplementation shows modest effects on fasting plasma glucose and insulin levels in type 2 diabetes.
  • Meta-analysis of nine studies reveals significant changes in biomarkers like HOMA-IR and hs-CRP after supplementation.
  • Clinical trials indicate a potential reduction in HbA1c by 0.30% and improved insulin sensitivity after 12 weeks.
  • Findings suggest vitamin D could help in managing diabetes, but the effects may diminish over time.

Cite This Study

Probosari et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf3c9https://doi.org/10.3390/nu17152489
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement2009 · 65,296 citations
  2. 2Vitamin D Supplementation: What's Known, What to Do, and What's Needed2012 · 79 citations
  3. 3Measuring inconsistency in meta-analyses2003 · 64,290 citations