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March 13, 2026Frontiers in Cardiovascular MedicineOpen Access

Intraoperative electroacupuncture reduces slow flow/no-reflow incidence ~80% vs standard PCI alone.

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Why the study?

Slow flow/no-reflow complicates up to 44% of PCIs for AMI, worsening prognosis, and clinical evidence for electroacupuncture mitigating this complication is limited.

Does intraoperative electroacupuncture reduce the incidence of slow flow/no-reflow in patients with acute myocardial infarction undergoing percutaneous coronary intervention?

Population

60 AMI patients undergoing PCI

Comparison

PCI with electroacupuncture vs PCI alone

Design

Single-center randomized assessor-blinded pilot trial

Follow-up

30 days

Key result

Electroacupuncture reduced the incidence of slow flow/no-reflow to 6.7% compared to 26.7% in the control group, yielding a risk ratio of 0.2.

Authors

XWXuqiang WeiYPYu PengKWKe Wang

Discussion

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Overview

Intraoperative electroacupuncture may reduce no-reflow in AMI PCI; leaves open routine adoption pending larger sham-controlled trials.

Key Points

  • This trial aimed to evaluate the feasibility and effectiveness of electroacupuncture in reducing slow flow/no-reflow during PCI for patients with acute myocardial infarction.
  • Single-center, randomized trial with 60 acute myocardial infarction patients
  • Participants received electroacupuncture or standard PCI
  • Outcome measures included slow flow/no-reflow incidence, pain, anxiety, and inflammatory markers
  • Electroacupuncture reduced slow flow/no-reflow incidence significantly (6.7% vs. 26.7%)
  • Median pain scores decreased significantly post-PCI
  • Anxiety scores were significantly lower post-PCI in the electroacupuncture group
  • Inflammatory markers were more favorable in the electroacupuncture group

Study Design

Type

RCT (n=60)

Blinding

Assessor-blinded

Randomization

1:1

Multicenter

No

Structured PICO

Does intraoperative electroacupuncture reduce the incidence of slow flow/no-reflow in patients with acute myocardial infarction undergoing percutaneous coronary intervention?

P
Population
60 adults with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI), mean age 63.2, 86.7% male, single-center (China).
I
Intervention
Intraoperative electroacupuncture (EA) stimulating bilateral Neiguan (PC6) and Ximen (PC4) acupoints (continuous 20-Hz pulses) during PCI.
C
Comparator
Standard percutaneous coronary intervention alone (control group).
O
Outcome
Incidence of slow flow/no-reflow (SF-NR) assessed via TIMI flow grade and corrected TIMI frame count (CTFC).surrogate

Main Result

Effect estimate: RR 0.2 (95% CI 0.0-0.4)

Absolute Event Rate: 6.7% vs 26.7%

p-value: p=.04

Intraoperative electroacupuncture during PCI for acute myocardial infarction is feasible and may reduce the incidence of slow flow/no-reflow and early inflammation, warranting larger sham-controlled trials.

Limitations

  • Single-center study, small sample size
  • Blinding limitations for acupuncturists and patients
  • Underpowered for secondary clinical outcomes
  • Small sample size
  • Single-center design
  • Lack of sham control (unblinded assessment for patients and acupuncturists)

Cite This Study

Wei et al. (2026) conducted an RCT in acute myocardial infarction (n=60). electroacupuncture vs. PCI alone was evaluated on incidence of slow flow/no-reflow (SF-NR) (RR 0.2, 95% CI 0.0-0.4, p=.04). Electroacupuncture reduced the incidence of slow flow/no-reflow to 6.7% compared to 26.7% in the control group, yielding a risk ratio of 0.2.

synapsesocial.com/papers/69b3aaa802a1e69014ccb77ahttps://doi.org/10.3389/fcvm.2026.1756414
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Also Consider

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  1. 1The challenges of coronary no‐reflow phenomenon2021 · 6 citations
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