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March 13, 2026SHILAP Revista de lepidopterologíaOpen Access

Efficacy evaluation of ultrasound-derived fat fraction in predicting of the severity of women with polycystic ovary syndrome and obesity

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Key result

PCOS is linked to ~100% higher UDFF in women with obesity versus obesity alone.

  • P<0.001
  • n=211

Why the study?

To investigate the feasibility of ultrasound-derived fat fraction as an evaluation index for obese women with polycystic ovary syndrome.

Does ultrasound-derived fat fraction (UDFF) correlate with metabolic and hormonal severity in obese women with polycystic ovary syndrome (PCOS)?

Population

103 women with PCOS and obesity and 108 obese women without PCOS

Comparison

Women with PCOS and obesity vs obese women without PCOS

Design

Case-control study

Authors

LMLina MengQingdao UniversityJWJ. WangGaozhou People's HospitalYLYong LiuJiangnan University

Discussion

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Implication

Supports UDFF for non-invasive metabolic severity assessment in obese PCOS; extends evidence but remains hypothesis-generating pending validation.

Key Points

  • To evaluate the feasibility of ultrasound-derived fat fraction as an objective metric for evaluating disease severity in obese women with polycystic ovary syndrome.
  • Enrolled 103 obese women with polycystic ovary syndrome (case group) and 108 obese women without polycystic ovary syndrome (control group).
  • Performed transvaginal three-dimensional ultrasound and hepatic ultrasound on menstrual cycle day 7 to measure hepatic fat fraction, shear wave velocity, ovarian morphology, and stromal hemodynamics.
  • Ultrasound-derived fat fraction was significantly higher in women with polycystic ovary syndrome and obesity than in controls without polycystic ovary syndrome (10.00% vs 5.00%, P < 0.001).
  • Stepwise logistic regression identified shear wave velocity, vascularization-flow index, ultrasound-derived fat fraction, resistance index, and low-density lipoprotein as independent risk factors, with the multivariate model achieving an area under the curve of 0.913.

Study Design

Type

Cohort (n=211)

Multicenter

No

Structured PICO

Does ultrasound-derived fat fraction (UDFF) correlate with metabolic and hormonal severity in obese women with polycystic ovary syndrome (PCOS)?

P
Population
211 premenopausal women over 18 years old with obesity (BMI ≥ 28 kg/m2), including 103 with a first diagnosis of polycystic ovary syndrome (PCOS) and 108 without PCOS.
I
Intervention
Measurement of hepatic ultrasound-derived fat fraction (UDFF) and shear wave velocity (SWV) alongside transvaginal 3D ultrasound
C
Comparator
Women without PCOS but with obesity (BMI ≥ 28 kg/m2)
O
Outcome
Diagnostic performance (AUC) of a multivariate model including UDFF, SWV, VFI, RI, and LDL for predicting PCOS, and correlation of UDFF with metabolic/hormonal indicessurrogate

Main Result

Absolute Event Rate: 10% vs 5%

p-value: p=<0.001

Hepatic ultrasound-derived fat fraction (UDFF) combined with other ultrasound and clinical markers provides a strong non-invasive diagnostic model for assessing the severity of metabolic and hormonal disorders in obese women with PCOS.

Limitations

  • Single-center design may lead to potential selection bias, limiting generalizability of results.
  • Subgroup analyses were not performed, complicating the verification of applicable scope for UDFF.
  • Residual confounding factors could not be completely excluded, including diet, physical activity, and medication history
  • Single-center design with clinic-based recruitment may lead to potential selection bias
  • Subgroup analyses were not performed, making it difficult to comprehensively verify the applicable scope and grading criteria for UDFF

Cite This Study

Meng et al. (2026) conducted a cohort in Polycystic Ovary Syndrome with Obesity (n=211). Ultrasound-derived fat fraction (UDFF) vs. Obese women without PCOS was evaluated on Comparison of ultrasound-derived fat fraction values between women with PCOS and obesity and control group (p=<0.001). Ultrasound-derived fat fraction (UDFF) values were significantly higher in women with polycystic ovary syndrome and obesity (10%) compared to those without PCOS (5%).

synapsesocial.com/papers/69b3aad702a1e69014ccb9b1https://doi.org/10.3389/fmed.2026.1779305
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Non‐invasive assessment of hepatic steatosis by ultrasound‐derived fat fraction in individuals at high‐risk for metabolic dysfunction‐associated steatotic liver disease2024 · 19 citations
  2. 2A potential link between polycystic ovary syndrome and non-alcoholic fatty liver disease: an update meta-analysis2018 · 133 citations
  3. 3Evaluation of ovarian microvascular structure in PCOS patients based on high-resolution ultrasound imaging technology2025 · 3 citations
  4. 4Liver stiffness quantification in biopsy-proven nonalcoholic fatty liver disease patients using shear wave elastography in comparison with transient elastography2021 · 21 citations
  5. 5Relationship between early follicular serum estrone level and other hormonal or ultrasonographic parameters in women with polycystic ovary syndrome2019 · 8 citations